Menstrual abnormalities after COVID-19 vaccines: A systematic review
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Authors
Nazir, Maheen
Asghar, Shumaila
Rathore, Muhammad Ali
Shahzad, Asima
Shahid, Anum
Khan, Alishba Ashraf
Malik, Asmara
Fakhar, Tehniat
Kausar, Hafsa
Malikg, Jahanzeb
Issue Date
2022-07-19
Type
Article
Language
en_US
Keywords
SARS-CoV-2 , Pandemic , Gynecology , Menorrhagia , Dysmenorrhea , Systematic Review , Menstrual Abnormalities
Alternative Title
Abstract
The objective of this systematic review is to give a comprehensive interpretation of menstrual cycle changes after the COVID-19 vaccination. Additionally, it is imperative to assess reports of menstrual changes following vaccination to dispel concerns that COVID-19 vaccines hinder the likelihood of pregnancy in the long run. A literature review was conducted using digital databases to systematically identify the studies reporting any menstrual abnormalities after the COVID-19 vaccine. Detailed patient-level study characteristics including the type of study, sample size, administered vaccines, and menstrual abnormalities were abstracted. A total of 78 138 vaccinated females were included in this review from 14 studies. Of these, 39 759 (52.05%) had some form of a menstrual problem after vaccination. Due to the lack of published research articles, preprints were also included in this review. Menorrhagia, metrorrhagia, and polymenorrhea were the most commonly observed problems and the overall study-level rate of menstrual abnormality ranged from 0.83% to 90.9%. Age, history of pregnancy, systemic side-effects of COVID-19, smoking, and second dose of COVID-19 vaccine were predictors of menstrual problems after vaccination.
Description
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Citation
Nazir, M., Asghar, S., Rathore, M. A., Shahzad, A., Shahid, A., Ashraf Khan, A., Malik, A., Fakhar, T., Kausar, H., & Malik, J. (2022). Menstrual abnormalities after COVID-19 vaccines: A systematic review. Vacunas, 23, S77–S87. https://doi.org/10.1016/j.vacun.2022.07.001
Publisher
Vacunas