Creatine as a promising component of paternal preconception diet
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Authors
Ostojic, Sergej M.
Stea, Tonje Holte
Engeset, Dagrun
Issue Date
2022-01-28
Type
Article
Language
en_US
Keywords
Fertility , Energy Metabolism , Creatine , Nutrition , Creatine Kinase
Alternative Title
Abstract
Male fertility has been declining globally over the past several decades, advancing from a personal issue to a public health problem. Beyond any doubt, a reduction in fertility (often characterized by low sperm count or motility) can severely threaten reproductive health and lifecourse framework in a long-term fashion. Aside from uncovering the currently unknown etiology of modern-day male infertility, the scientific and medical community faces a double burden: finding an efficient biomarker of impaired fertility and exploring any intervention that can act to enhance fertility. A plethora of nutritional compounds have been recognized as possible modulators of semen quality, and specific dietary patterns and nutrients appear to be accompanied by a lower risk of male infertility. Creatine, a conditionally essential nutrient, has caught attention as a male fertility-promoting candidate due to its role in sperm energy metabolism. This mini-review describes the creatine-related bioenergetics of spermatozoa, explores a connection between creatine levels and sperm quality in men, and critically examines available evidence for interventional studies with creatine to affect sperm viability.
Description
Citation
Ostojic, S. M., Stea, T. H., & Engeset, D. (2022). Creatine as a Promising Component of Paternal Preconception Diet. Nutrients, 14(3), 586. https://doi.org/10.3390/nu14030586
Publisher
Nutrients