Regulation of male fertility by the renin-angiotensin system
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Authors
Gianzo, Marta
Subirán, Nerea
Issue Date
2020-10-26
Type
Article
Language
en_US
Keywords
Renin-Angiotensin System , Male Infertility , Angiotensin , Renin , Testis , Spermatozoa
Alternative Title
Abstract
The renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that acts locally through different paracrine and autocrine mechanisms. In the male reproductive system, several components of this system have been observed in various organs and tissues, such as the testes, spermatozoa and seminal fluid. Some functions attributed to this local RAS are maintenance of seminal plasma electrolytes, regulation of steroidogenesis and spermatogenesis, and sperm functions. However, their specific actions in these locations are not fully understood. Therefore, a deep knowledge of the functions of the RAS at both the testicular and seminal levels could clarify its roles in male infertility and sperm physiology, and the different RAS elements could be used to design tools enabling the diagnosis and/or treatment of male infertility.
Description
Citation
Gianzo, M., & Subirán, N. (2020). Regulation of Male Fertility by the Renin-Angiotensin System. International journal of molecular sciences, 21(21), 7943. https://doi.org/10.3390/ijms21217943
Publisher
International Journal of Molecular Sciences