Rac1 is dispensable for oocyte maturation and female fertility in vivo
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Authors
Hao, Jian-Xiu
Meng, Tie-Gang
Fan, Li-Hua
Yao, Yuan-Qing
Issue Date
2017-05-18
Type
Article
Language
en_US
Keywords
Female Fertility , Oocyte Maturation
Alternative Title
Abstract
Oocyte maturation, the important process to produce female haploid gamete, accompanies with polarity establishment and highly asymmetric cell division to emit minor polar body within little cytoplasm. Microfilaments play central roles in polarity establishment and asymmetric cell division. Several actin regulators like WASP protein family as well as small GTPases function in microfilament dynamics, involving the process. Rac1, one member of RhoGTPases, has been reported to regulate the polarity and asymmetric cell division in mouse oocytes in vitro. The physiological role of Rac1 in mouse oocyte remains unknown. By conditional knockout technology, we specifically deleted Rac1 gene in mouse oocyte, and found that Rac1 deletion exerted little effect on mouse oocyte maturation including polarity establishment and asymmetric division, and the mutant mice showed normal fertility.
Description
Citation
Hao, J. X., Meng, T. G., Fan, L. H., & Yao, Y. Q. (2017). Rac1 is dispensable for oocyte maturation and female fertility in vivo. PloS one, 12(5), e0177202. https://doi.org/10.1371/journal.pone.0177202
Publisher
PloS One