Coronavirus: a possible cause of reduced male fertility
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Authors
Huang, Chuan
Ji, Xiren
Zhou, Wenjun
Huang, Zhenghui
Peng, Xiangjie
Fan, Liqing
Lin, Ge
Zhu, Wenbing
Issue Date
2020-10-11
Type
Article
Language
en_US
Keywords
Coronavirus , SARS‐CoV‐2 , Male Fertility
Alternative Title
Abstract
In lately December 2019, a novel coronavirus (SARS‐CoV‐2) outbreak occurred in Wuhan, PR China. It is a high contagious virus that has threatened human health worldwide. SARS‐CoV‐2 infection, termed COVID‐19, causes rapidly developing lung lesions that can lead to multiple organ failure in a short period. Whenever a novel virus emerges, reproductive risk assessments should be performed after infection. In this review, we show that male fertility might be damaged by coronavirus associated with (i) direct cytopathic effects derived from viral replication and viral dissemination in the testis; and (ii) indirect damage to male fertility derived from immunopathology. In this review, we briefly describe the impaired fertility of humans and animals infected with coronaviruses to deduce the impact of the new coronavirus on male fertility. Together with information related to other coronaviruses, we extrapolate this knowledge to the new coronavirus SARS‐CoV‐2, which may have a significant impact on our understanding of the pathophysiology of this new virus.
Description
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
Citation
Huang, C., Ji, X., Zhou, W., Huang, Z., Peng, X., Fan, L., Lin, G., & Zhu, W. (2021). Coronavirus: A possible cause of reduced male fertility. Andrology, 9(1), 80–87. https://doi.org/10.1111/andr.12907
Publisher
Andrology