The Catsper channel and its roles in male fertility: a systematic review

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dc.contributor.authorSun, Xiang-hong
dc.contributor.authorZhu, Ying-ying
dc.contributor.authorWang, Lin
dc.contributor.authorLiu, Hong-ling
dc.contributor.authorLing, Yong
dc.contributor.authorLi, Zong-li
dc.contributor.authorSun, Li-bo
dc.date.accessioned2022-10-06T02:43:27Z
dc.date.available2022-10-06T02:43:27Z
dc.date.issued2017-08-15
dc.description.abstractThe Catsper channel is a sperm-specific, Ca2+-permeable, pH-dependent, and low voltage-dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction. All of these physiological events require calcium entry into sperm cells. Remarkably, Catsper genes are exclusively expressed in the testis during spermatogenesis, and are sensitive to ion channel-induced pH change, such as NHEs, Ca2+ATPase, K+ channel, Hv1 channel and HCO3 − transporters. Furthermore, the Catsper channel is regulated by some physiological stimulants, such as progesterone, cyclic nucleotides (e.g., cAMP, cGMP), zona pellucida (ZP) glycoproteins and bovine serum albumin (BSA). All of these factors normally stimulate Ca2+ entry into sperm through the Catsper channel. In addition, the Catsper channel may be a potential target for male infertility treatment or contraception. This review will focus on the structure, functions, regulation mechanisms and medicinal targets of the Catsper channel.en_US
dc.identifier.citationSun, X. H., Zhu, Y. Y., Wang, L., Liu, H. L., Ling, Y., Li, Z. L., & Sun, L. B. (2017). The Catsper channel and its roles in male fertility: a systematic review. Reproductive biology and endocrinology : RB&E, 15(1), 65. https://doi.org/10.1186/s12958-017-0281-2en_US
dc.identifier.otherDOI: 10.1186/s12958-017-0281-2
dc.identifier.urihttps://hdl.handle.net/20.500.14041/2195
dc.language.isoen_USen_US
dc.publisherReproductive Biology and Endocrinologyen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCatsper Channelen_US
dc.subjectCa2+ Signalen_US
dc.subjectMale Infertilityen_US
dc.subjectMedicineen_US
dc.titleThe Catsper channel and its roles in male fertility: a systematic reviewen_US
dc.typeArticleen_US
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