New insights into human endometrial aminopeptidases in both implantation and menstruation
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Authors
Mizutani, Shigehiko
Matsumoto, Kunio
Kato, Yukio
Mizutani, Eita
Mizutani, Hidesuke
Iwase, Akira
Shibata, Kiyosumi
Issue Date
2019
Type
Article
Language
en_US
Keywords
Aminopeptidase A , Angiotensin-II , Endometrium , Membrane Permeability , Placental Leucine Aminopeptidase , Menstruation
Alternative Title
Abstract
The endometrium cycle involves proliferation of endometrial epithelial cells in preparation for implantation of fertilized ovum. With ovulation, the endometrium secretes nutrients such as peptides and amino acids into the endometrial cavity. The histological evidence of ovulation in normal menstrual cycle includes subnuclear glycogen vacuoles surrounded by placental leucine aminopeptidase (P-LAP) in endometrial epithelial cells. P-LAP is an essentially involved in intracellular trafficking of glucose transporter (GLUT) 4 which is primarily important for glucose uptake in skeletal muscles and fat tissues. On the other hand, glucose influx from blood into endometrial epithelial cells is not mainly mediated by GLUTs, but by coincident appearing progesterone just after ovulation. Progesterone increases permeability of not only plasma membranes, but also lysosomal membranes, and this may be primarily involved in glucose influx. Progesterone also expands the exocytosis in the endometrium after ovulation, and endometrial secretion after ovulation is possibly apocrine and holocrine, which is augmented and exaggerated exocytosis of the lysosomal contents. The endometrial spiral arteries/arterioles are surrounded by endometrial stromal cells which are differentiated into decidual/pre-decidual cells. Decidual cells are devoid of aminopeptidase A (APA), possibly leading to enhancement of Angiotensin-II action in decidual cell area due to loss of its degradation by APA. Angiotensin-II is thought to exert growth-factor-like effects in post-implantation embryos in decidual cells, thereby contributing to implantation. Without implantation, angiotensin-II constricts the endometrial spiral arteries/arterioles to promote menstruation. Thus, P-LAP and APA may be involved in homeostasis in uterus via regulating glucose transport and vasoconstrictive peptides.
Description
Citation
Mizutani, S., Matsumoto, K., Kato, Y., Mizutani, E., Mizutani, H., Iwase, A., & Shibata, K. (2020). New insights into human endometrial aminopeptidases in both implantation and menstruation. Biochimica et biophysica acta. Proteins and proteomics, 1868(2), 140332. https://doi.org/10.1016/j.bbapap.2019.140332
Publisher
Proteins and Proteomics