The role of mutant p63 in female fertility
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Authors
Luan, Yi
Xu, Pauline
Yu, Seok-Yeong
Kim, So-Youn
Issue Date
2021-08-20
Type
Article
Language
en_US
Keywords
Female Fertility , Epidermal Development , Mutant
Alternative Title
Abstract
The transcription factor p63, one of the p53 family members, plays an essential role in regulating maternal reproduction and genomic integrity as well as epidermal development. TP63 (human)/Trp63 (mouse) produces multiple isoforms: TAp63 and ΔNp63, which possess a different N-terminus depending on two different promoters, and p63a, p63b, p63g, p63δ, and p63ε as products of alternative splicing at the C-terminus. TAp63 expression turns on in the nuclei of primordial germ cells in females and is maintained mainly in the oocyte nuclei of immature follicles. It has been established that TAp63 is the genomic guardian in oocytes of the female ovaries and plays a central role in determining the oocyte fate upon oocyte damage. Lately, there is increasing evidence that TP63 mutations are connected with female infertility, including isolated premature ovarian insufficiency (POI) and syndromic POI. Here, we review the biological functions of p63 in females and discuss the consequences of p63 mutations, which result in infertility in human patients.
Description
Citation
Luan, Y., Xu, P., Yu, S. Y., & Kim, S. Y. (2021). The Role of Mutant p63 in Female Fertility. International journal of molecular sciences, 22(16), 8968. https://doi.org/10.3390/ijms22168968
Publisher
International Journal of Molecular Sciences