Modulation of platelet functions assessment during menstruation and ovulatory phases
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Authors
Alzahrani, Faisal
Hassan, Fathelrahman
Issue Date
2019-07
Type
Article
Language
en_US
Keywords
17β-Estradiol , Menstruation Cycle , Hemostasis , Platelets
Alternative Title
Abstract
During menstruation, endometrial hemostasis is achieved by platelet aggregation, fibrin deposition, and thrombus formation that interact with local endocrine and immunological factors which cause termination of menstrual bleeding. Interactions between steroidal sex hormones and platelet functions are not well understood. The aim of this study was to evaluate the effect of platelet function during the menstrual cycle and luteal phase in women of reproductive age. The cross-sectional study on women of reproductive age included 44 healthy women. Platelet function was assessed by PFA-100TM analyzer with collagen/epinephrine and collagen/ADP cartridges during the menstrual cycle and luteal phase. There were no significant differences in platelet function between menstruation and ovulatory phase. Platelet activity in Arab collagen/epinephrine cartridge increased during menstruation compared to non-Arab ethnic subjects and no significant differences in platelet function were found when using collagen/ADP cartridge. This study suggested modulation in platelet functions during menstruation and luteal phase in women of reproductive age. Further studies, including a large number of subjects, platelet genetic and progesterone factors change in platelet clotting associated to menstrual cycle should be conducted.
Description
Citation
Alzahrani, F., & Hassan, F. (2019). Modulation of Platelet Functions Assessment during Menstruation and Ovulatory Phases. Journal of medicine and life, 12(3), 296–300. https://doi.org/10.25122/jml-2019-0005
Publisher
Journal of Medicine and Life