Immune aspects of female infertility
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Authors
Brazdova, Andrea
Senechal, Helene
Peltre, Gabriel
Poncet, Pascal
Issue Date
2016-04-05
Type
Article
Language
en_US
Keywords
Immunoglobulins , Immune Aspects , Female Infertility
Alternative Title
Abstract
Immune infertility, in terms of reproductive failure, has become a serious health issue involving approximately 1 out of 5 couples at reproductive age. Semen that is defined as a complex fluid containing sperm, cellular vesicles and other cells and components, could sensitize the female genital tract. The immune rejection of male semen in the female reproductive tract is explained as the failure of natural tolerance leading to local and/or systemic immune response. Present active immune mechanism may induce high levels of anti-seminal/sperm antibodies. It has already been proven that iso-immunization is associated with infertility. Comprehensive studies with regards to the identification of antibody-targets and the determination of specific antibody class contribute to the development of effective immuno-therapy and, on the other hand, potential immuno-contraception, and then of course to complex patient diagnosis. This review summarizes the aspects of female immune infertility.
Description
Citation
Brazdova, A., Senechal, H., Peltre, G., & Poncet, P. (2016). Immune Aspects of Female Infertility. International journal of fertility & sterility, 10(1), 1–10. https://doi.org/10.22074/ijfs.2016.4762
Publisher
International Journal of Fertility & Sterility