Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis
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Authors
Purandhar, Kaveri
Jena, Prasant Kumar
Prajapati, Bhumika
Rajput, Parth
Seshadri, Sriram
Issue Date
2014-12-29
Type
Article
Language
en_US
Keywords
Aging , Heat-shock Proteins , Mitochondria , Male Fertility
Alternative Title
Abstract
Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance to environmental stress, while mitochondria are primary targets in the process of aging, their expression decreasing with age. Mitochondrion also plays a significant role in the process of spermatogenesis. HSPs have been shown to be involved in apoptosis with some of acting as apoptotic inhibitors and are involved in cytoprotection. In this review we discuss the roles of Hsp 27, 60, 70, and 90 in aging and male infertility and have concluded that these particular HSPs can be used as a molecular markers for mitochondrially- mediated apoptosis, aging and male infertility.
Description
Citation
Purandhar, K., Jena, P. K., Prajapati, B., Rajput, P., & Seshadri, S. (2014). Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis. The world journal of men's health, 32(3), 123–132. https://doi.org/10.5534/wjmh.2014.32.3.123
Publisher
The World Journal of Men's Health