The association between mutations in ubiquitin-specific protease 26 ( USP26) and male infertility: a systematic review and meta-analysis
Loading...
Authors
Li, Qin-Yu
Zhang, Yu-Cong
Wei, Chao
Liu, Zhuo
Song, Guo-Da
Chen, Bing-Liang
Liu, Man
Liu, Ji-Hong
Wu, Li-Cheng
Liu, Xia-Ming
Issue Date
2022-07
Type
Article
Language
en_US
Keywords
Male Infertility , Azoospermia , Ubiquitin-specific Protease 26 , Systematic Review , Meta-Analysis
Alternative Title
Abstract
During recent decades, the association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility remains doubtful. We conducted this meta-analysis to evaluate the association between mutations in USP26 and male infertility according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. It was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42021225251). PubMed, Web of Science, and Scopus were systematically searched for comparative clinical studies, which were written in English and provided eligible data. Studies were included when they compared USP26 mutations in azoospermic, oligozoospermic, and asthenozoospermic patients with controls with normal sperm parameter values or whose partners had experienced spontaneous pregnancy. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated with random effect models. Overall, twelve studies with 3927 infertility patients and 4648 healthy controls were included. The association between overall USP26 mutations and infertility was not significant (OR = 1.60, 95% CI: 0.51-5.01). For specific mutations, the pooled ORs were 1.65 (95% CI: 1.02-2.69) for cluster mutation (including 370-371insACA, 494T>C, and 1423C>T), 1.80 (95% CI: 0.35-9.15) for c.576G>A, 1.43 (95% CI: 0.79-2.56) for c.1090C>T, and 3.59 (95% CI: 2.30-5.59) for c.1737G>A. Our results suggest that several mutations (cluster mutation, c.1737G>A) may play roles in male infertility, while others (c.576G>A and c.1090C>T) do not show notable associations with male infertility. More high-quality clinical researches are needed for validation.
Description
Citation
Li, Q. Y., Zhang, Y. C., Wei, C., Liu, Z., Song, G. D., Chen, B. L., Liu, M., Liu, J. H., Wu, L. C., & Liu, X. M. (2022). The association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility: a systematic review and meta-analysis. Asian journal of andrology, 24(4), 422–429. https://doi.org/10.4103/aja2021109
Publisher
Asian Journal of Andrology