Dietary cholesterol and lipid overload: impact on male fertility
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Authors
Saez, Fabrice
Drevet, Joël R.
Issue Date
2019-12-06
Type
Article
Language
en_US
Keywords
Dietary Cholesterol , Lipid Overload , Male Fertility
Alternative Title
Abstract
Lipid metabolic disorders due to poor eating habits are on the rise in both developed and developing countries, with a negative impact of the “Western diet” on sperm count and quality. Dietary lipid imbalance can involve cholesterol, fatty acids, or both, under different pathophysiological conditions grouped under the term dyslipidemia. The general feature of dyslipidemia is the development of systemic oxidative stress, a well-known deleterious factor for the quality of male gametes and associated with infertility. Sperm are particularly rich in polyunsaturated fatty acids (PUFA), an important characteristic associated with normal sperm physiology and reproductive outcomes, but also targets of choice for oxidative thrust. This review focuses on the effects of dietary cholesterol or different fatty acid overload on sperm composition and function in both animals and humans. The links between oxidative stress induced by dyslipidemia and sperm dysfunction are then discussed, including possible preventive or therapeutic strategies to preserve gamete quality, longevity when stored in cryobanking, and male fertility.
Description
Citation
Saez, F., & Drevet, J. R. (2019). Dietary Cholesterol and Lipid Overload: Impact on Male Fertility. Oxidative medicine and cellular longevity, 2019, 4521786. https://doi.org/10.1155/2019/4521786
Publisher
Oxidative Medicine and Cellular Longevity