Menstrual abnormalities post-COVID vaccination: a cross-sectional study on adult Lebanese women
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Authors
Dabbousi, Ahmad Ayman
Masri, Jad El
Ayoubi, Lemir Majed El
Ismail, Omar
Zreika, Bachir
Salameh, Pascale
Issue Date
2022-07-26
Type
Article
Language
en_US
Keywords
Adverse Events , COVID-19 , Menstrual Irregularities , Vaccination
Alternative Title
Abstract
Background:
In the year 2020, the coronavirus pandemic invaded the world. Since then, specialized companies began to compete, producing many vaccines. Coronavirus vaccines have different adverse events. Menstrual disorders have been noticed as a common complaint post-vaccination.
Aim:
Our study fills an important gap by evaluating the relationship between coronavirus vaccines and menstrual disorders.
Methods:
This is a cross-sectional study between 20 September 2021, and 1 October 2021, using an online survey. The questionnaire consisted of 36 questions divided into 4 sections: demographics, COVID-19 exposure and vaccination, hormonal background, and details about the menstrual cycle. Sample t-test, ANOVA test, chi-square, and McNemar test were used in bivariate analysis.
Results:
This study includes 505 Lebanese adult women vaccinated against COVID-19. After vaccination, the number of women having heavy bleeding or light bleeding increased (p = 0.02 and p < 0.001, respectively). The number of women having regular cycles decreased after taking the vaccine (p < 0.001). Irregularity in the cycle post-vaccination was associated with worse PMS symptoms (p = 0.036). Women using hormonal contraception method or using any hormonal therapy had higher menstrual irregularity rates (p = 0.002 and p = 0.043, respectively). Concerning vaccine adverse events, those who had headaches had a higher rate of irregularity (p = 0.041). Those having PCOS, osteoporosis, or blood coagulation disorders had higher irregularity rate (p < 0.001 and p = 0.005, respectively).
Conclusion:
Vaccine adverse events may include specific menstrual irregularities. Moreover, some hormonal medications and diseases are associated with the alteration of the menstrual cycle. This study helps in predicting vaccines’ menstrual adverse events, especially in a specific population prone to menstrual disorders.
Description
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
Citation
Dabbousi, A. A., El Masri, J., El Ayoubi, L. M., Ismail, O., Zreika, B., & Salameh, P. (2022). Menstrual abnormalities post-COVID vaccination: a cross-sectional study on adult Lebanese women. Irish journal of medical science, 1–8. Advance online publication. https://doi.org/10.1007/s11845-022-03089-5
Publisher
Irish Journal of Medical Science