Coenzyme Q10 and Male Infertility: A Systematic Review
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Authors
Salvio, Gianmaria
Cutini, Melissa
Ciarloni, Alessandro
Giovannini, Lara
Perrone, Michele
Balercia, Giancarlo
Issue Date
2021-05-30
Type
Article
Language
en_US
Keywords
Idiopathic Oligoasthenozoospermia , Male Infertility , Oxidative Stress , Coenzyme Q10
Alternative Title
Abstract
Infertility affects 15% of couples worldwide. A male factor is involved in 50% of cases. The etiology of male infertility is poorly understood, but there is evidence for a strong association between oxidative stress (OS) and poor seminal fluid quality. For this reason, therapy with antioxidants is one of the cornerstones of empirical treatment of male infertility. Coenzyme Q10 (CoQ10)-an essential cofactor for energy production with major antioxidant properties-is commonly used to support spermatogenesis in idiopathic male infertility. This systematic review aims to elucidate the usefulness of CoQ10 supplementation in the treatment of male infertility, particularly with regard to semen quality assessed by conventional and advanced methods, and pregnancy rates. All studies report a beneficial effect of CoQ10 supplementation on semen parameters, although randomized controlled trials are a minority. Moreover, the optimal dosage of CoQ10 or how it can be combined with other antioxidant molecules to maximize its effect is unknown. However, CoQ10 is still one of the most promising molecules to treat idiopathic male infertility and warrants further investigation.
Description
Citation
Salvio, G., Cutini, M., Ciarloni, A., Giovannini, L., Perrone, M., & Balercia, G. (2021). Coenzyme Q10 and Male Infertility: A Systematic Review. Antioxidants (Basel, Switzerland), 10(6), 874. https://doi.org/10.3390/antiox10060874
Publisher
Antioxidants (Basel, Switzerland)