Treatment of Leukocytospermia in Male Infertility: A Systematic Review
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Authors
Jung, Jae Hung
Kim, Myung Ha
Kim, Jiye
Baik, Soon Koo
Koh, Sang-Baek
Park, Hyun Jun
Seo, Ju Tae
Issue Date
2016-12
Type
Article
Language
en_US
Keywords
Leukocyte , Male Infertility , Semen Analysis , Therapeutics
Alternative Title
Abstract
Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive oxygen free radicals produced inside cellular mitochondria as a result of inflammation. The present review reveals that antibiotics might improve sperm parameters, the rate of resolution of leukocytospermia, the bacteriologic cure rate, and even the pregnancy rate, although some reports conflict. Antioxidants might also have clinical benefits for sperm function as shown by in vitro studies. However, the data are insufficient to conclude whether antibiotics and antioxidants for the treatment of infertile men with leukocytospermia are effective or not. Better designed investigations into leukocytospermia are needed.
Description
Citation
Jung, J. H., Kim, M. H., Kim, J., Baik, S. K., Koh, S. B., Park, H. J., & Seo, J. T. (2016). Treatment of Leukocytospermia in Male Infertility: A Systematic Review. The world journal of men's health, 34(3), 165–172. https://doi.org/10.5534/wjmh.2016.34.3.165
Publisher
The World Journal of Men's Health