Tachykinins and kisspeptins in the regulation of human male fertility
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Authors
Blasco, Víctor
Pinto, Francisco M.
González-Ravina, Cristina
Santamaría-López, Esther
Candenas, Luz
Fernández-Sánchez, Manuel
Issue Date
2019-12-31
Type
Article
Language
en_US
Keywords
Tachykinin , Kisspeptin , Neurokinin , Male Infertility , Assisted Reproductive Technology
Alternative Title
Abstract
Infertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility.
Description
Citation
Blasco, V., Pinto, F. M., González-Ravina, C., Santamaría-López, E., Candenas, L., & Fernández-Sánchez, M. (2019). Tachykinins and Kisspeptins in the Regulation of Human Male Fertility. Journal of clinical medicine, 9(1), 113. https://doi.org/10.3390/jcm9010113
Publisher
Journal of Clinical Medicine