Covid-19, vaccination, and female fertility in the Czech Republic
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Authors
Kolatorova, Lucie
Adamcova, Karolina
Vitku, Jana
Horackova, Lenka
Simkova, Marketa
Hornova, Marketa
Vosatkova, Michala
Vaisova, Veronika
Parizek, Antonin
Duskova, Michaela
Issue Date
2022-09-18
Type
Article
Language
en_US
Keywords
COVID-19 , Vaccination , Infection , Woman Fertility , Antral Follicle Count , Steroids
Alternative Title
Abstract
The fast-track process to approve vaccines against COVID-19 has raised questions about their safety, especially in relation to fertility. Over the last 2 years, studies have appeared monitoring female fertility, especially from assisted reproduction centers or in animal experiments. However, studies monitoring healthy populations are still limited. The aim of our study was to monitor the relevant parameters of female fertility (sex and other steroids, LH, FSH, SHBG, Antimüllerian hormone and antral follicle count) before and then 2–4 months after the third dose of vaccination against COVID-19 in a group of 25 healthy fertile woman. In addition, anti-SARS-CoV-2 and anti-SARS-CoV-2S antibodies were determined. We did not observe significant changes in the measured parameters before and after the third dose of vaccination. By comparing levels of the analytes with antibodies indicating a prior COVID-19 infection, we found that women who had experienced the disease had statistically lower levels of estrone, estradiol, SHBG and 5α-dihydroprogesterone, and conversely, higher levels of androgen active dehydroepiandrosterone and dihydrotestosterone. Our results confirm that vaccination does not affect female fertility, and that what fertile women should be worried about is not vaccination, but rather COVID-19 infection itself.
Description
Citation
Kolatorova, L., Adamcova, K., Vitku, J., Horackova, L., Simkova, M., Hornova, M., Vosatkova, M., Vaisova, V., Parizek, A., & Duskova, M. (2022). COVID-19, Vaccination, and Female Fertility in the Czech Republic. International journal of molecular sciences, 23(18), 10909. https://doi.org/10.3390/ijms231810909
Publisher
International Journal of Molecular Sciences