Quality of life and sexual health in the aging of PCa survivors
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Authors
Gacci, Mauro
Baldi, Elisabetta
Tamburrino, Lara
Detti, Beatrice
Livi, Lorenzo
Nunzio, Cosimo De
Tubaro, Andrea
Gravas, Stavros
Carini, Marco
Serni, Sergio
Issue Date
2014-03-17
Type
Article
Language
en_US
Keywords
Quality of Life , Sexual Health , Aging of PCa Survivors
Alternative Title
Abstract
Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.
Description
Citation
Gacci, M., Baldi, E., Tamburrino, L., Detti, B., Livi, L., De Nunzio, C., Tubaro, A., Gravas, S., Carini, M., & Serni, S. (2014). Quality of Life and Sexual Health in the Aging of PCa Survivors. International journal of endocrinology, 2014, 470592. https://doi.org/10.1155/2014/470592
Publisher
International Journal of Endocrinology