Urinary bisphenol a levels and male fertility
Loading...
Authors
Radwan, Michał
Wielgomas, Bartosz
Dziewirska, Emila
Radwan, Paweł
Kałużny, Paweł
Klimowska, Anna
Hanke, Wojciech
Jurewicz, Joanna
Issue Date
2018-09-27
Type
Article
Language
en_US
Keywords
Environmental Exposure To Bisphenol A , Semen Quality , DNA Fragmentation , Sperm Aneuploidy
Alternative Title
Abstract
Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility and, results are divergent. The aim of the study is to examine the associations between urinary BPA concentration and male fertility. Bisphenol A urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men under 45 years of age with normal sperm concentration (⩾15 mln/ml) recruited from a male reproductive health clinic. Participants were interviewed and provided a semen sample. BPA was detected in 98.10% of urine samples, with a median concentration of 1.87 µg/l (1.63 µg/ g creatinine). A multiple linear regression analysis identified a positive association between the urinary concentrations of bisphenol A 25th–50th percentile and total sperm sex chromosome disomy (p = .004). Also when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy (p = .01). Urinary concentration of BPA also increase the percentage of immature sperm (HDS) (p = .018) and decrease motility (p = .03). The study provides evidence that exposure to BPA is associated with poorer semen quality. Future studies are needed to confirm these findings.
Description
Citation
Radwan, M., Wielgomas, B., Dziewirska, E., Radwan, P., Kałużny, P., Klimowska, A., Hanke, W., & Jurewicz, J. (2018). Urinary Bisphenol A Levels and Male Fertility. American journal of men's health, 12(6), 2144–2151. https://doi.org/10.1177/1557988318799163
Publisher
American Journal of Men's Health