Testing as prevention of resistance in bacteria causing sexually transmitted infections—a population-based model for Germany

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dc.contributor.authorHahn, Andreas
dc.contributor.authorFrickmann, Hagen
dc.contributor.authorLoderstädt, Ulrike
dc.date.accessioned2023-04-11T01:55:17Z
dc.date.available2023-04-11T01:55:17Z
dc.date.issued2021-07-30
dc.description.abstractPrescribed antibiotic treatments which do not match the therapeutic requirements of potentially co-existing undetected sexually transmitted infections (STIs) can facilitate the selection of antibiotic-drug-resistant clones. To reduce this risk, this modelling assessed the potential applicability of reliable rapid molecular test assays targeting bacterial STI prior to the prescription of antibiotic drugs. The modelling was based on the prevalence of three bacterial STIs in German heterosexual and men-having-sex-with-men (MSM) populations, as well as on reported test characteristics of respective assays. In the case of the application of rapid molecular STI assays for screening, the numbers needed to test in order to correctly identify any of the included bacterial STIs ranged from 103 to 104 for the heterosexual population and from 5 to 14 for the MSM population. The number needed to harm—defined as getting a false negative result for any of the STIs and a false positive signal for another one, potentially leading to an even more inappropriate adaptation of antibiotic therapy than without any STI screening—was at least 208,995 for the heterosexuals and 16,977 for the MSM. Therefore, the screening approach may indeed be suitable to avoid unnecessary selective pressure on bacterial causes of sexually transmitted infections.en_US
dc.identifier.citationHahn, A., Frickmann, H., & Loderstädt, U. (2021). Testing as Prevention of Resistance in Bacteria Causing Sexually Transmitted Infections-A Population-Based Model for Germany. Antibiotics (Basel, Switzerland), 10(8), 929. https://doi.org/10.3390/antibiotics10080929en_US
dc.identifier.otherDOI: 10.3390/antibiotics10080929
dc.identifier.urihttps://hdl.handle.net/20.500.14041/6224
dc.language.isoen_USen_US
dc.publisherAntibioticsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectResistanceen_US
dc.subjectSexually Transmitted Infectionen_US
dc.subjectPreventionen_US
dc.subjectTestingen_US
dc.subjectModellingen_US
dc.subjectNeisseria Gonorrhoeaeen_US
dc.subjectChlamydia Trachomatisen_US
dc.subjectMycoplasma Genitaliumen_US
dc.titleTesting as prevention of resistance in bacteria causing sexually transmitted infections—a population-based model for Germanyen_US
dc.typeArticleen_US
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