Sirtuin functions in female fertility: possible role in oxidative stress and aging
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Authors
Tatone, Carla
Di Emidio, Giovanna
Vitti, Maurizio
Di Carlo, Michela
Santini, Silvano Jr.
D'Alessandro, Anna Maria
Falone, Stefano
Amicarelli, Fernanda
Issue Date
2015-05-05
Type
Article
Language
en_US
Keywords
Sirtuin Functions , Female Fertility , Oxidative Stress
Alternative Title
Abstract
In search for strategies aimed at preventing oxidative threat to female fertility, a possible role of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity, are emerging as key antiaging molecules and regulators in many diseases. Recently, a crucial role for SIRT1 and SIRT3, the main components of sirtuin family, as sensors and guardians of the redox state in oocytes, granulosa cells, and early embryos has emerged. In this context, the aim of the present review is to summarize current knowledge from research papers on the role of sirtuins in female fertility with particular emphasis on the impairment of SIRT1 signalling with oocyte aging. On this basis, the authors wish to build up a framework to promote research on the possible role of sirtuins as targets for future strategies for female fertility preservation.
Description
Citation
Tatone, C., Di Emidio, G., Vitti, M., Di Carlo, M., Santini, S., Jr, D'Alessandro, A. M., Falone, S., & Amicarelli, F. (2015). Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. Oxidative medicine and cellular longevity, 2015, 659687. https://doi.org/10.1155/2015/659687
Publisher
Oxidative Medicine and Cellular Longevity