Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases
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Authors
Liu, Ting
Shi, Fuli
Ying, Ying
Chen, Qiongfeng
Tang, Zhimin
Lin, Hui
Issue Date
2020-10-07
Type
Article
Language
en_US
Keywords
Mouse Model , Menstruation , Gynaecological Diseases
Alternative Title
Abstract
Abnormal menstruation may result in several pathological alterations and gynaecological diseases, including endometriosis, menstrual pain and miscarriage. However, the pathogenesis of menstruation remains unclear due to the limited number of animal models available to study the menstrual cycle. In recent years, an effective, reproducible, and highly adaptive mouse model to study menstruation has been developed. In this model, progesterone and oestrogen were administered in cycles following the removal of ovaries. Subsequently, endometrial decidualisation was induced using sesame oil, followed by withdrawal of progesterone administration. Vaginal bleeding in mice is similar to that in humans. Therefore, the use of mice as a model organism to study the mechanism of menstruation and gynaecological diseases may prove to be an important breakthrough. The present review is focussed ond the development and applications of a mouse model of menstruation. Furthermore, various studies have been described to improve this model and the research findings that may aid in the treatment of menstrual disorders in women are presented.
Description
Citation
Liu, T., Shi, F., Ying, Y., Chen, Q., Tang, Z., & Lin, H. (2020). Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review). Molecular medicine reports, 22(6), 4463–4474. https://doi.org/10.3892/mmr.2020.11567
Publisher
Molecular Medicine Reports