Renin angiotensin system, covid-19 and male fertility: any risk for conceiving?
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Authors
Pascolo, Lorella
Zito, Gabriella
Zupin, Luisa
Luppi, Stefania
Giolo, Elena
Martinelli, Monica
Rocco, Daniela De
Crovella, Sergio
Ricci, Giuseppe
Issue Date
2020-09-28
Type
Article
Language
en_US
Keywords
Male Fertility , SARS-CoV-2 , COVID-19
Alternative Title
Abstract
The current knowledge concerning the connection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the renin–angiotensin system (RAS) system in the male reproductive apparatus is still limited, so dedicated studies are urgently required. Concerns about the male fertility consequences of SARS-CoV-2 infection have started to emerge, since epidemiologic studies observed that this coronavirus affects male patients more frequently and with increased severity, possibly because of the hormone-regulated expression of angiotensin-converting enzyme 2 (ACE2) receptor. A disturbance in fertility is also expected based on studies of the previous SARS-CoV infection, which targets the same ACE2 receptor when entering the host cells. In addition, bioinformatics analyses reveal the abundant expression of ACE2 receptor in the male reproductive tissues, particularly in the testis. It has been proposed that pharmacological intervention favoring the angiotensin-(1–7)/ACE2/Mas receptor pathway and increasing ACE2 expression and activity could greatly prevent inflammatory lesions in this area. Finally, in laboratories performing assisted reproductive technologies it is recommended that more attention should be paid not only to sperm quality but also to safety aspects. Data about the potential infectivity of seminal fluid are in fact conflicting and do not exclude risks for both personnel and patients. The potential infectivity of SARS-CoV-2 in reproductive male tissues should be strongly considered and further investigated for the proper management of in vitro fertilization procedures.
Description
Citation
Pascolo, L., Zito, G., Zupin, L., Luppi, S., Giolo, E., Martinelli, M., De Rocco, D., Crovella, S., & Ricci, G. (2020). Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving?. Microorganisms, 8(10), 1492. https://doi.org/10.3390/microorganisms8101492
Publisher
Microorganisms