Chronic inflammation impairs male fertility—a case-control study in ulcerative colitis patients
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Authors
Wdowiak, Artur
Gujski, Mariusz
Bojar, Iwona
Raczkiewicz, Dorota
Bartosińska, Joanna
Wdowiak-Filip, Anita
Filip, Rafał
Issue Date
2021-04-02
Type
Article
Language
en_US
Keywords
Inflammatory Bowel Disease , Ulcerative Colitis , Semen Analysis , Antisperm Antibodies , Oxidation-Reduction Potential , Male Sex Hormones , Bacterial Infection
Alternative Title
Abstract
Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. The control group consists of 50 healthy volunteers. Total sperm count, sperm count, percentage of morphologically normal spermatozoa, viability, and progressive motility, are significantly lower in the study group than in healthy males (p < 0.001). The DNA fragmentation index (DFI) and oxidation-reduction potential (ORP) are significantly higher in the study group (28.9% and 1.55% on average, respectively) than in healthy males (14.6% and 0.79% on average, respectively). Bacteriospermia is more clearly observed in the study group (p = 0.037), and the most frequent pathogen is Enterococcus faecalis. The DFI and ORP are significantly higher in bacteria carriers, compared to males without microbial pathogens from both the study and control groups (p < 0.001). To conclude, UC patients have worse basic sperm parameters compared to their healthy counterparts. Deterioration of semen parameters, as well as an intensified DNA fragmentation could be a result of oxidative stress intensification.
Description
Citation
Wdowiak, A., Gujski, M., Bojar, I., Raczkiewicz, D., Bartosińska, J., Wdowiak-Filip, A., & Filip, R. (2021). Chronic Inflammation Impairs Male Fertility-A Case-Control Study in Ulcerative Colitis Patients. Journal of clinical medicine, 10(7), 1460. https://doi.org/10.3390/jcm10071460
Publisher
Journal of Clinical Medicine