Challenges presented by re-emerging sexually transmitted infections in HIV positive men who have sex with men: an observational study of lymphogranuloma venereum in the UK
Loading...
Authors
Rönn, Minttu
Hughes, Gwenda
Simms, Ian
Ison, Cathy
Alexander, Sarah
White, Peter J
Ward, Helen
Issue Date
2014-08-01
Type
Article
Language
en_US
Keywords
Sexually Transmitted Infections , Lymphogranuloma Venereum , HIV , Men Who Have Sex With Men
Alternative Title
Abstract
Background:
United Kingdom has reported the largest documented outbreak of lymphogranuloma venereum (LGV), a re-emerging sexually transmitted infection (STI) which is primarily seen in HIV-positive men who have sex with men (MSM). A diagnostic service was established in response to the outbreak linked to a voluntary LGV Enhanced Surveillance system. We examined the performance of this novel surveillance system to identify utility in tracking a re-emerging infection.
Methods:
We described laboratory data on samples and surveillance data from case reports for LGV from 2004-2010. We performed a cross-sectional analysis comparing clinical and behavioural characteristics of HIV-positive and HIV-negative/unknown LGV cases diagnosed in MSM using multivariable logistic regression models with generalised estimating equations to control for repeat infections.
Results:
LGV Surveillance data were available for 87% (1,370/1,581) of LGV cases (after de-duplication). There were 1,342 episodes in 1,281 MSM, most of whom were known to be HIV-positive (1,028/1,281, 80.2%,). HIV-positive men reported a shorter duration of symptoms (aOR 0.5; 95%CI 0.3, 0.8 for reporting more than a week compared to a week or less) in comparison to HIV-negative/unknown MSM, and were more likely to report unprotected receptive anal intercourse (aOR 2.7; 95% CI 1.3, 5.8).
Conclusion:
The surveillance identified the population at greater risk of infection based on higher levels of risk behaviour in HIV-positive LGV cases. However, there was diagnostic bias towards HIV-positive LGV cases who presented with a shorter duration of symptoms when compared to HIV-negative/unknown LGV cases.
Description
Citation
Rönn, M., Hughes, G., Simms, I., Ison, C., Alexander, S., White, P. J., & Ward, H. (2014). Challenges Presented by Re-Emerging Sexually Transmitted Infections in HIV Positive Men who have Sex with Men: An Observational Study of Lymphogranuloma Venereum in the UK. Journal of AIDS & clinical research, 5(8), 1000329. https://doi.org/10.4172/2155-6113.1000329
Publisher
Journal of AIDS & Clinical Research