The effectiveness and safety of traditional Chinese herbal medicine for the treatment of male infertility associated with sperm DNA fragmentation: A protocol for systematic review and meta-analysis
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Authors
Li, Qingrui
Zhang, Chao
Li, Chenxi
Lin, Xuyao
Wang, Mingkai
Wu, Lin
Li, Hua
Ye, Pule
Qin, Guozheng
Issue Date
2021-03-05
Type
Article
Language
en_US
Keywords
DNA Fragmentation , Male Infertility , Drugs, Chinese Herbal , Spermatozoa , Systematic Review , Meta-Analysis
Alternative Title
Abstract
Background: Sperm DNA fragmentation (SDF) may hinder embryonic development and growth, increasing the risk of spontaneous miscarriage, and is considered an important factor affecting male infertility (MI). Traditional Chinese herbal medicine is considered effective in the treatment of MI due to SDF by nourishing kidney essence or promoting blood circulation for removing blood stasis. The objective of this systematic review protocol is to evaluate the effectiveness and safety of traditional Chinese herbal medicine on the treatment of MI associated with SDF.
Methods: We searched the PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP Chinese Science, Technology Journal Database, and Wanfang Database until the end of 2020 for English and Chinese published literature. Randomized controlled trials (RCTs) to evaluate the effectiveness and safety of traditional Chinese herbal medicine for the treatment of MI associated with SDF will be included. Study selection and data extraction were performed independently by 2 reviewers, and the quality evaluation and risk assessment were assessed by the Cochrane collaboration's tool, and use the RevMan 5.3 software for meta-analysis.
Conclusion: This study will evaluate the efficacy and safety of traditional Chinese herbal medicine for the treatment of MI due to SDF, which may provide some help for the clinician's decision.
Description
Citation
Li, Q., Zhang, C., Li, C., Lin, X., Wang, M., Wu, L., Li, H., Ye, P., & Qin, G. (2021). The effectiveness and safety of traditional Chinese herbal medicine for the treatment of male infertility associated with sperm DNA fragmentation: A protocol for systematic review and meta-analysis. Medicine, 100(9), e24918. https://doi.org/10.1097/MD.0000000000024918
Publisher
Medicine